IMO, if United's players don't have injury issues, or team fitness issues.
manchester united has a long list of injured players, such as:
Anthony Martial = is expected to be fully recovered by April 2nd
Raphael Varane = also has a prediction that he will be recovered from April 2nd
Marcus Rashford = is also expected to be fully recovered by April 2nd
Casemiro = will be able to play from April 15th
all these players will need some time to get their rhythm, I don't know if they will be able to give their all in the game against sevilla, but looking at sevilla's poor performance i think manchester united has a lot of great chances to win in this game, but if sevilla in these games if they show a different team, i.e. they have a good performance then it will be very difficult for manchester united to beat them, sevilla will have games against teams that are also not doing well in the league while manchester united will have very difficult games in the premier league, so we can have an idea of how much each team has improved or deteriorated
Anthony Martial has not been included in Ten Hag's starting line-up, the worry is Marcus Rashford. but according to several sources that I read, Marcus Rashdord recovered from his injury. however, he is a doubt for the game against Newcastle this weekend. but could be involved in some capacity.
As for Raphael Varane, Ten Hag has confirmed that the problem is not serious and the defender is available for the game against Newcastle. as for Casemiro, he is out through suspension after receiving his second red card of the season against Southampton. that means, he will miss three matches in the Premier League.
However we will see his next appearance in the Europa League against Sevilla on April 13. aat least, I don't see that they are problematic for this competition. but for the Premier League, the absence of some players may have quite an effect on the team's overall performance.
For the match versus Sevilla later, I'm still optimistic, Manchester United will win the battle. apart from having the advantage of playing as the home team in the first leg, Sevilla's performance is in a very bad trend. at least, on paper United have a higher chance than their opponents, we can also draw that from the odds available for these two teams.