In my opinion it is much more difficult to win in express bets than in single bets because one wrong prediction leads to a loss. We all know that the higher the risk the bigger the reward can be, so if you correctly predict the outcomes of all the matches, you'll make a very good profit.
Personally, I think my analytical knowledge is not enough to win in express bets, so I prefer to make single bets.
You are right, 99 percent of all my express bets always end in loss, and like the OP said, this most of the time happen between third, second or last game.
But I've found a way around this, what I do now is that if I place an express bet of let's say 10 bets in one slip, when the games are on, I simply monitor it, I lf luck is on my side and I won the first seven games, by this, I am already in good profit, so I will just request a cash out, it is saver this way than waiting to see if I will win everything whereas I end up losing it all by just one incorrect bet.