So do you think it is worth it to do some rigs on Awesome Miner single coin, and some rigs use Nice Hash and use profit switching?
Depends on what you're aiming to:
If you're interested in a certain coin, then profit doesn't matter. You need that coin no matter what (developing stuff or whatever the coin is used for)
If you want to play the market and probably cash higher in the long run, then you should mine a profitable coin and probably hold it until the market price is good for you. However you don't know exactly when this will happen.
I you don't want to be bothered with exchanges, then you could use services like MininPoolHub that do the exchange for you. However you're still earning the coins you mine and the service do the exchange to whatever you want. The exchange gamble still applies. Only difference is that you don't get to decide when to exchange, because this is done automatically. You could have mined at a profitable time but the service exchanges at a lower price. The opposite can also be true.
Also, since you're earning in coins and these services have minimums for exchanges, the more different coins you mine the longer it takes to reach a minimum for exchange on each coin. This is because your hashing power gets divided into more coins.
With services like NiceHash you don't need to be worried about the coin market that much, because profits comes from whatever is most wanted in the NiceHash market (that your hardware can mine). Of course, it's very likely that the most profitable coins in the cryptocurrency market are the most wanted in the NiceHash market. Also, it doesn't matter which algorithm you mine, you're always paid in BTC at the profit of the moment of mining. That is, every time you send a valid share it is added to your balance at the current exchange rate (BTC price / algorithm price). And they have fixed days for payment so you always know when you're going to cash.
IMO if you're looking for quick profit with no hassle, services like NiceHash are the way to go. But these services are not necessarily the most profitable in a longer window of time.
The good thing is, AwesomeMiner can be used in any of these scenarios.