It is possible, though I haven't heard of it. Anything is possible when you are locking up hardware. It is not a situation where there is much control.
When you add up the time lost in mining from people locking up their GPUs or rigs and the value of the time a person puts into overclocking, I think most people come away with a net loss. Had they just left everything stock, they would have been solid mining 24/7, probably more actual shares mined anyway, not to mention the time they would have saved. Don't even get me started on people overclocking for highest mhash number on the screen and not even looking at what they've done to their actual shares submitted rate, or the power per hash ratio.
Good points. I was able find stable OC's on my other rig very easily... not sure why this one is giving me so much grief, lol. I just wasnt checking the other OC's as gpu0 was always indicated as the one with the issue, now that I disregard that, I should have more luck I'm guessing. I just got stuck on that fact that gpu0 kept getting returned to stock.... now that i know that I should not always use that as an indicator, I bet I'm good to go as revisit my other OC's (once its run stock stable for awhile). Still going strong.