Reinstalling the OS is the absolute minimum you should do.
You'll get most malware removed with a wipe of the hard drive + reinstalling the OS.
However, the theoretical risk of rootkits still exists. Reinstalling the OS won't help you there.
But the chances aren't very high to have a computer infected with a good (in terms of professional) root kit.
But since it is going to be used as an offline storage, you shouldn't be worried too much about that.
Like HCP said, what if my friend wants to go online occasionally on this PC? What exactly is to be done with that root kits thing? And can't they do anything with the certificates/signatures installed for each app before and after?
And going online through a smartphone (via HotSpot) or through WiFi Modem (Broadband service) makes any difference? He wants to use PC as an offline storage for crypto, but does that mean that he cannot go online even for other curricular things he needs to do in life?