...if you're holding huge amounts of bitcoin or cryptocurrencies in general, as always, I heavily suggest purchasing a hardware wallet like the Trezor[1] or the Ledger Nano S[2] *** If you don't hold much bitcoin, like probably sub $500, a mobile wallet like Mycelium[3] should be enough.
I get that you are just talking in generalities here, but I am curious as to what you consider to be "huge amounts" so as to warrant a hardware wallet and how you came up with the sub $500 in value suitable for a more economical mobile wallet (with the supposed implication that the higher security hardware wallet is not really necessary for anything below $500).
[disclosure = not my intention to attack your logic or reasoning, because you obviously have to draw the line
somewhere]
I'm going to guess your rationale is probably based on the cost of a Trezor or Ledger itself... If you only have $500 in BTC value - why would you spend roughly 20% of that on a more secure wallet when there are any other less expensive options out there? Seems a bit expensive!
But the guy who today holds $500 in BTC had nearly $3000 in value for the same amount of BTC just over a year ago (if my math is right). Buying a hardware wallet would have cost the same amount in fiat money on both ends of that timeline, but the value of the cryptos on it has changed drastically. It has fallen, but according to many it can rise back up to and surpass that high water mark. Nobody knows for sure how much value the HODL guy with $500 in current BTC stands to lose if he chooses a less secure storage method for his Bitcoin in February of 2019 and is subsequently hacked or loses his paper wallet and then somehow John McAfee's li'l buddy is spared and the BTC price skyrockets!
I guess what I am saying is that if it is worth protecting, it is worth protecting ... ... within reason - I wouldn't recommend someone buy a hardware wallet to store 10,000 satoshi. But in saying that, I suppose I've done the very same thing as you in making a personal judgment on what amount is worth protecting and what amount is just throwing it all away.
(Just for frame of reference, I'm holding less than $300 in BTC and I have all but a very small amount of it on a Trezor).