There are real estate websites for buying property in Crypto but Im not sure how they facilitate that.
Procedural handling will be no different from transactions using fiat, but because it involves a large amount of funds then I would not trust online real estate agents without making sure they have a physical office.
Loyce has created an interesting thread about properties that can be owned for 1 bitcoin in several countries. Apart from that, you also have to have a reference to the legality of bitcoin in each country so that you don't face legal problems later.