You should use the default intensities for more speed. The default intensity for the 1080ti is 24
THIS IS A CHANGE--
The last version assigned "-i 21" as default. I tried higher intensities, and anything greater than "-i 23 "resulted in failure. This time I started where I left off, and did not go further. Profitability is low, even if performance is high. I have better coins to mine.
As for use of "The Pill", it is harmless when not needed, and helps when needed. I game with it. --scryptr