I did a short 40 minute test when Claymore did the original Nicehash Dagger support over a month ago - everything looked OK, no rejects!
The Nicehash Decred stratum has around 1.9% reject rate, which again is acceptable.
Obviously, a lot of people who do not want to own GPU's (heat and noise reasons) can purchase hashpower at Nicehash at up to 9% discount - varies with the bidding process.
However, you need a really good mining pool, with fast servers and fast Alt coin network to make those tight margins work out.