There are "material technical distinctions" between LTC and BTC.
No there aren't. Stop it.
1) 4x Supply.
This one should be obviously irrelevant. I won't bother unless you disagree.
2) 1/4 Block times.
First off, there are effectively zero use-cases where 2.5mins is acceptable but 10mins isn't, especially when you overlay the statistical variance on those numbers. They're both terrible for the retail buy-a-cup-of-coffee scenario; 0-conf will have to be accepted for both coins. And for the usual online-purchase scenario, waiting an hour for full conf is just fine.
It's also worth noting that it's unproven how litecoin will perform at scale with the different constants. Orphans may be an issue; and there are convincing arguments for it still taking close to an hour to get full security no matter what the block-time, due to the nature of blockchain-style global-consensus.
3) Scrypt.
Originally supposed to be GPU resistant, and until recently, called "asic-proof" by promoters....neither is true at all. ASICs for litecoin are being built now, with order-of-magnitude improvement over GPU litecoin mining. The arms race will be similar to bitcoin's in the end.
4) "Optimizations"
We'll see what the ltc dev team comes up with, but because the bitcoin and litecoin codebases are so similar, it's fairly reasonable to assume that any materially beneficial improvements made to one will eventually be incorporated into the other.
Note that I think the alt experimentation is great, and I've come to believe that there's value in a strong (but not too strong) technically-similar alt chain as "insurance" to the dominant chain, along with some trading/liquidity benefits. But I'd still hope that if an alt DID get within an order of magnitude of bitcoin, it'd have distinct technical advantages that bitcoin hadn't-yet or couldn't incorporate.