Applying anything at the Advanced page removes the overclock with immediate effect.
To restart the overclock just do /config/zzz.sh restart or whatever file you use.
So basically when tweaking the voltages whenever you hit Apply you need to restart the overclock file via SSH
I would suggest to install BFGminer - it is much easier to tweak as you can see the hash rate of each individual board.
Restart modified .sh again after making any changes on Advanced page.
Thank you both
I had just modified the existing cgminer.sh, restarted the miner and although I can see shares at the pool I've lost http & ssh access so will need to carry on tweaking tomorrow when I have physical access to reboot it manually.