See Israel's new cases - https://graphics.reuters.com/world-coronavirus-tracker-and-maps/countries-and-territories/israel/
Roughly 80+ of the population is fully vaccinated with large portions of the population receiving boosters, yet they are experiencing the worst peak since the start of the pandemic, adding 50k+ cases as of late. Israel also conducted a study administering a 4th shot which saw no clinical efficacy in stopping COVID transmission, one of the first in the world.
Some speculation that ADE can arise when administering vaccines - https://www.nature.com/articles/s41564-020-00789-5
Quote
One potential hurdle for antibody-based vaccines and therapeutics is the risk of exacerbating COVID-19 severity via antibody-dependent enhancement (ADE). ADE can increase the severity of multiple viral infections, including other respiratory viruses such as respiratory syncytial virus (RSV) and measles. ADE in respiratory infections is included in a broader category named enhanced respiratory disease (ERD), which also includes non-antibody-based mechanisms such as cytokine cascades and cell-mediated immunopathology. ADE caused by enhanced viral replication has been observed for other viruses that infect macrophages, including dengue virus and feline infectious peritonitis virus (FIPV). Furthermore, ADE and ERD has been reported for SARS-CoV and MERS-CoV both in vitro and in vivo. The extent to which ADE contributes to COVID-19 immunopathology is being actively investigated.
Add this issue on top of omicron being so genetically distant from the original strain, you have useless vaccines in terms of stopping transmission.
