The Spartan's typically used were $150 each. Even if bought for $100, that's only maybe ~270MH/$100. I'm not knowledgeable on all the pricing (bulk or otherwise), but wouldn't an Artix be proportionately as costly - if not more?
I would expect them to be substantially _less_ costly per MH. E.g. fitting potentially 400-900MH/s in an $100 part. Beyond the basic process improvements the Artix/Kintex parts have a substantially improved architecture. Of course, the S6LX150 designs have had a lot of effort applied to optimizing them.
If I'm not mistaken, an Avalon is about ~280MH/BTC.08 (today's rate that equates to ~280MH/$5.50). So, unless you can purchase an FPGA with a performance/cost that beats that, then I don't know how this can work. Perhaps, this is just an academic pursuit for you.
A batch 3 Avalon cost 75 BTC and delivers 68GH/s. At the current market price that is $75/GHs. So maybe a 28nm FPGA ends up being twice the price per MH initially. But: It would have a smaller basic unit size (probably a 2 or 4 chip board) which would create a larger customer base and it could potentially have better supply. What does it matter that _in theory_ an Avalon is $75/GHs now when you can't actually buy one??
Plus, once there is a ASIC miner on a better process in widespread use the avalons will either need to head to the landfill— or at least Alaska for use as heating units, while a 28nm FPGA may have better reusablity.
I imagine that if someone had a board like the x6500 based on artix _right now_ they would be selling out. In a month? who knows.
So I don't think this is interesting just as a novelty project... though if it's just an "okay idea that won't make much money" vs an amazing one depends a lot on how the asic miner supply plays out, how the bitcoin market price plays out, etc.