EDIT: one is AP6502 and one is AP6502A
Your 5V*500mA calculation is based on the quiescent load I assume. So when there's no load the converter would use 2.5W.
Potentially the AP6502A would deliver 90%*2A*5V (assuming the Efficiency graph with Vout =3.3V is similar to the 1.2Vout) = 9W
USB (normal port) give 500mA 5V (miinus cable loss). No load current is minimal. I can't find 9W USB ports. Thank you clarifying AP6502 and AP6502A are diffrent chips. I missed it.
But AP6502 and AP6502A have very similiar efficiency curves. In 3.3v range efficiency peaks 90% but not in 1.2V range. It is quite sure AP6502A 1.2V efficiency are 70-80% range in 2A current. Avalon best is 6.6W/Ghash 1.15v but normal operating 1.2v or little more if OC'd. 0.285Mhash * 6.6w=1.88w (at best) or 1.4A. From modules 164W per 80chips -> 2.05W per chip @1.2v -> 1.71A.
If AP6502A efficiency is 75% @1.2v 1.71A it takes 2.73W in. Over USB limit.
Datasheet note add schotky diode to improve efficiency. But no data how much it helps or are efficiency graphs with or without diode.
--> nano may work in normal 500mW USB port, but it should undervolt/clocked. 1.2A charge USB works fine for nano2.