You're right, it's unfair to compare Osasuna and Atletico Bilbao, even in the standings we can see the difference between these two teams this season. And if it was Atletico Bilbao who did it, I agree it would probably be more difficult for Real Madrid to turn things around.
Atletico Bilbao is a tough opponent for Real Madrid, they must not underestimate their opponents this time. Atletico Bilbao has the ability to make Real Madrid lose points in this match, especially since they really need a win to maintain their position so they can stay in the top 4 standings.
Whatever Atletico Bilbao will do to get them points in this match, they will appear full of motivation to beat Real Madrid. Meanwhile for Real Madrid, they also need to win, because if they lose they will be closer to their closest competitor, and that is something that is not good for them. This is a home match for Real Madrid, they must be able to ensure they can give a win to their supporters in the stadium and make them comfortable at the top of the standings.
From the results obtained from the previous 5 matches, it is very unfair to compare Bilbao with Genoa and everyone knows that Genoa is not a strong team in Laliga compared to Bilbao which has a much better performance and is stronger in terms of depth Bilbao players are far superior.
Certainly Bilbao will be a very difficult opponent for Real Madrid and Bilbao even though they will be playing away from home, but Bilbao could get 1 point to hold the match to a draw.
There is only a chance that Real Madrid will win or end in a draw in the upcoming match.
Talking about Bilbao's desire to win and get 3 points, it seems like it will also be very difficult because away games are always a difficult challenge to beat Real Madrid, whereas everyone knows how Real Madrid plays at home, always giving very good results.
Even though both clubs want to get additional points, in my opinion it would be better if Bilbao had to be careful not to lose points or end the match with a draw.
Compared to Bilbao forcing to beat Real Madrid but conceding instead, it is better to divide the score to 1 point which is much better.