In terms of conditions PSV is clearly more advantaged in this match because after all they play home and this will clearly benefit with their performance in domestic competitions that are very good where 7 matches managed to pass with a victory but in terms of experience Sevilla is clearly much bigger for the Champions League.
Sevilla must try to get 3 points or at least 1 point in this match because indeed this can further break their spirit for further matches in La Liga especially for the next few weeks there are matches against Madrid and Arsenal which surely this will not be easy if they lose momentum in this match and against Vallecano.
Sevilla were nearly beating PSV despite that bad performance. I mean PSV were dominating the game in general but Sevilla still managed to score 2 goals. They even answered PSV's second goal in a very short time. But the goal PSV scored in the last moments of the stoppage time devastated Sevilla players as they were dreaming of a win.
Still their group is in decent condition for Sevilla though. Because Lens managed to beat Arsenal surprisingly. But Sevilla will need to get some wins on the upcoming weeks otherwise we might see them in the Europa League once again.