We will have to see how it turns out this weekend. As you say, Madrid are favourites in their match, and Barcelona have a tougher game against Atletico Madrid on Saturday. A draw or loss for Barcelona could give psychological encouragement to Madrid, who could then take the league lead on Sunday if Saturday's result is a draw, or come second behind Atletico but ahead of Barcelona if Atletico beat Barca. It's going to be interesting.
Real Madrid playing at home against Sevilla, I believe it will be a victory that Real Madrid will definitely get. Because after all, although Real Madrid is still not completely perfect so far this season, but the fact is that Sevilla has a bad trend from the last few seasons. After all, although Real Madrid is not completely consistent, but Real Madrid is still Real Madrid who will always have the chance to get good results in every match. Thus, I believe this will be a very good chance for Real Madrid to get three points, moreover Barcelona has also experienced a decline in performance lately.
Yes, I also think that Madrid are favourites over Sevilla, and if I had to bet on them I would bet on them, although I only bet on sports betting from time to time, and also in this case I am sure that the bookies are underpaying for Madrid's victory.
Considering this factor, I believe it is difficult for Barcelona to be able to beat Atletico, which is currently that Barcelona and Atletico have the same points. So, if for example Barcelona and Atletico end the match with a draw, it will certainly make Real Madrid top the standings if Real Madrid manages to win against Sevilla, but I personally believe Real Madrid will win and thus,I believe Barcelona will be overtaken by Real Madrid.
What I find exciting about this is that we have a third party in the fight for the league, which in this case is Atletico Madrid, and that if they win they will take the lead, plus they have played a game less.