I know that for the time being, low circulating supply means that the coin will increase in value but how low can it get before it starts to give diminishing returns and actually inflict damage to the system? What would happen to crypto in general if all of the coins and altcoins will suffer the same ending?
There is absolutely no way to get access to them in case of lost keys and hard drives, so the possibility of these lost coins to be ever traded is 99.999999999... %.
I just hope that in 100 years a solution will be found to "zero" them out in order not to confuse all other users of bitcoin.