In 2013, John Doe I. may lose his 400 USD or 10 BTC wallet.
In 2014, John Doe II. may lose his 400 USD or 1 BTC wallet.
In 2015, John Doe III. may lose his 400 USD or 0.1 BTC wallet.
This pretty much covers the problem in its entirety. The average user stands to lose less and less every year. However, I think that the security of Bitcoin holdings will increase and people will figure out how to handle inheritance, etc etc. So I don't believe there will be a fixed percentage of lost coins, it will likely be a smaller percentage in the future. When and if Bitcoin hits mainstream, there could be a temporary spike in lost coins due to negligent use.
It's already increased. Multiple backups, online wallets (themselves backed up). I don't think we're going to see anywhere near a loss rate of 2% yearly. More like .2%.