Most of the losing slot players always use a high bet amount just to increase their potential profit while they didn’t consider their bankroll is not in proportion to their bet already.
Patience is a good strategy for slot games but it doesn't mean you can't still run into losses, just that the losing rate will be minimal since it will take you a while before staking again after you must have won or lose. Though the minimization of losses in slot games is not only dependent on patience alone because even while a gambler is patient enough before staking the next bet but if he is playing with a huge amount at any time he decides to play, huge losses cannot still be avoided in such circumstance.
Actually, staking with low amounts while you still practice patience is a good strategy because you will not experience too many losses since you are using a little amount and being very patient before staking each bets. High bet amounts can be disastrous because you can lose a whole lot of money within a very short interval, though there are people that can decide that instead of spending a lot of time gambling with low amounts and involving patience, they will prefer to use that amount and stake at once, if they don't win, they quit at that moment and give attention to other things.