Not possible. Max per channel is 256 bits.
Quick note, kramble; the max is actually 511-bits.
Does the X6500 use JTAG for communication or does it use some more effective protocol?
It uses JTAG. There is an FTDI chip on there that allows bit-banging pins over USB, and so compatible software bit-bangs JTAG to talk to the FPGA. The entire protocol sitting on top of JTAG is described in
jtag_comm.v.
I've trawled this topic and github but am still not sure what the best starting point for a new (Kintex7-325) fpga miner would be.
I would recommend starting with the
X6000_ztex_comm4 project. That's the same code that generated the bitstreams on the fpgamining.com website. You'll want to remove the jtag communication related code and replace it with serial communication, or something else. You can then multi-core that and exchange some resources for DSP48s as iidx mentioned.
It's also possible to implement a miner using only DSP48s and misc. logic, achieving about 500MH/s. I haven't released any code for that yet.