Are you mining Bitcoin or another SHA-256 coin? If so, you might want to look at buying an ASIC instead of more video cards/USB miners, as they are a lot stronger than your USB miners/video cards. Video cards are pretty good for mining other coins like ETH where no ASICs exist though. Look into AntMiners or Avalons if you want to get a set up that actually mines a decent amount of Bitcoin.
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Yes, Bitcoin. I guess I'm going to look into a real ASIC miner. I'm just not sure how to set it up.
I assume it needs its own power supply? Do I connect it to windows, my Raspberry Pi?
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If you buy an Antminer all you need is a PSU and a Ethernet cable. Once connected the setup is easy.