Right now as we speak any cheap mixer with small fees would be losing money under $5k and the more expensive ones under 1k, so of course it's affecting the business, but ...big blocks are bad! Cause...reasons!
any "cheap" mixer with small commissions are already a bad thing.. because their internal middlemen systems of shuffling coins(hops) are not much hense why they are not charging much commission(they dont have many self transfer fee's when shuffling internally).. thus the chain analysis companies can easily link inflows and outflows. especially ones advertised as "fast" too (less possibilities)
but yes any service.. mixers included, that do many spam hops of 1-confirms to shuffle coins will see costs multiply making it expensive to use a service, so people will stop using services.. as seen and pointed out by yourself
..
however you will see the mixers that do SOME middle-man shuffling do LESS of it to cut their costs.. so many "good" mixers with better pattern obfuscation will do less spam hopping of shuffling coins of their internal custody/reserves.. to save cost but to try to stay in operation. so expect this to happen
bad obfuscation ("cheap" "fast" mixers) go out of business because they cant afford to run while still "cheap commission"
bad obfuscation ("cheap" "fast" mixers) change their commission to try to survive
good obfuscation ("commission is x# multiple fee" mixers) go out of business because they cant afford to run while still "x# multiple fee"
good obfuscation ("commission is x# multiple fee" mixers) turn to bad obfuscation by cutting down on the middleman processes