To be honest, I don't really know the Slavia Prague squad. However, referring to the two matches they played in this competition, Slavia Prague won the match smoothly without conceding. while AS Roma is in 2nd place even though they have the same 6 points. the difference is, Slavia Prague scored more goals. Also, they haven't conceded a goal at all. Meanwhile, Roma conceded one goal in their 2 matches and scored 6 goals. Even though Roma's performance is not very impressive in domestic competitions, they have quite a big chance in this group G phase. Moreover, the bookies favor AS Roma in the meeting against Slavia Prague.
Referring to the predicted line-up of players and the pattern that Mourinho will implement, it is very likely that he will rest several important players. However, it seems that Lukaku will continue to play as the main starter. In this match, Mourinho could use a 3-5-2 pattern. referring to betting options, Roma with @1.69 and while Slavia Prague @5.80. It is clear from a betting perspective that Jose Mourinho's squad is superior. I am referring to the ideal betting option. but what makes it a little interesting is, betting on both teams to score goals with odds @ 2.10.
My estimate is that Roma will win this match. however, both teams will score. My guess is, the final score ends with 2-1
Roma showed a different side when playing on the Europa League stage, their performance was different from that in Serie A. Two matches were swept clean with wins, thus placing them in second place in Group G. The match between Roma versus Slavia Prague this time will be decisive and confirming their position in the group, while maintaining their hopes of qualifying as winners of group G. I agree with you, if you look at the odds given by the bookie, it is clear that Roma can secure full points this time, however, Slavia Prague could do otherwise.
On the other hand, Jose Mourinho is very ambitious to bring Roma to success in winning the Europa League trophy this season, after successfully winning the Europa Conference League previously. Personally, I don't doubt his experience in European competitions, but Roma is not the only team that is favored this time, Liverpool and Laverkusen also have the same big chance.