and of course the trust of the traders/investors is very impotant
Exchanges are closing not because of they don't have traders but either due to they got hacked or due to government regulation they can't meet the requirement to continue exchanges so they will end up closing the exchanges. I too think that Bittrex may survive for long but can't say with full guaranty.
We can hope for the prevail of our favorite exchanges like the Bittrex but actually, we cant know for sure if this exchange will survive an ongoing wave of the new exchanges that are releasing their own coins and also the direct onslaught of the governments which are actually full of greed.
Their greed is getting so high that they are banning exchange transfers to FIAT due to increasement of the investors in the crypto market.
On a long-term, we will see but we cannot tell for sure what will happen.
Exchanges with the potential will survive but even that best secured may be hacked or even revealed as the corrupted.