With the central bank often bailing troubled banks out (not considering whether it's good in the long term on the economy scale). And in many countries money in the deposits of individuals is often insured to some extent too. Obviously, the situation is much better now than it was in the 19th century...
The central bank means the multiple smaller bank runs and depressions of the 19th century (1800s) will be delayed into one HUMONGOUS apocalyptic TBTF failure coming before 2024 and lasting through 2033.
I've already noticed somewhere that you don't quite understand what FRB actually means. For an economy as whole this is a zero sum game because for every loan given out by a bank there is a deposit put into the bank (or somewhere in the system). Fractional in FRB means that a bank retains only a portion of deposits as reserves, but this in no case means that the bank can issue more loans than it has in deposits. Strictly speaking, it can actually issue more loans than it has in its customers' deposits, but it will have to close the gap as soon as possible (within the same day, if I'm not mistaken). A bank can fail only if it has a bank-run or its debtors default (or both) whereas it is not able to revoke loans or get help from outside, but this couldn't fail the whole system for the central bank which would just offset financial assets and liabilities, socializing the likely net loss through inflation...
