We could never function well when we are on that condition so it's better to just let it go and play when we are better.
just imagine trying to beat the system when you are not 100% well, you'll know the outcome already, so don't be surprise if you lose.
If it's a skilled based games you're playing, the same outcome may happen as you won't be able to use your skills well when you are under the influence of an alcohol or drugs on that matter.
It again depends from a person. While being normal, person might be silent or boring, but after a doze of alcohol he becomes nicest and funniest guy. And if there is such a person at the gambling table, the game becomes more fun. And of course there are type of people who are ready to lose from the start (they deposit not to earn profit, but to have a great time). Nevertheless, in general it isnt advisable to do something and expect high results when you can dedicate 100% of you to that.