Definitely Lyon don't seem like they will have a chance against Monaco, considering they are at the bottom of the table and have a relatively weak form this season although they had a win in their last five matches they are still at the bottom of the table and it's very clear Monaco will not want to loose to a team at the bottom of the table at their home, the worse that could happen, is the game ending in a draw. If Monaco happens to get a go first, then you can be sure they are most definitely going to win because so far in the french Ligue 1, they are the only team who has won all their game in which they had the first goal leading their opponent, they have done it in six game so far this season and they won all six.
It was also felt that Lyon's previous victory was not enough to be a reference for beating Monaco and maybe they will make it a little difficult for Monaco in this match. Monaco must win and as you said, the distance will also be reduced from PSG and this will open up the competition between the two to become even more heated. On the other hand, PSG will face quite difficult opponents, namely Lille and Monaco, of course they hope that Lille will be able to overthrow PSG this week.