If you talk about Chelsea is really hard to say if they'd win or not and same goes to Fulham but the main focus should be on Chelsea because they're the bigger boys but these days is like they should be classified as smaller team base on performance.
This season is very hard for the Blues to even get a draw talkless of a win, I'd say Fulham are going to do anything possible to get a win that's if Pochettino decide to do some wrong selection.
And head to head both Chelsea teams are superior to Fulham and Chelsea won three wins, one draw and also one defeat against Fulham. And I think Pochettino will plan and give his best in front of his supporters and will field his best squad to win this match, even though every Chelsea match is always in doubt, but for this match I think they can win it.