Surely this will be a serious problem for Arsenal ahead of their big match against Manchester City later, Bukayo Saka's muscle injury problem is serious enough that he was pulled off the field in the previous match against Lens, and obviously this is a serious concern for Arteta because as we know Saka is one of the important players on their wing. Of course as you say this situation is really very unfortunate when they have to play a big team like Manchester City but they have to lose their key players. Oh well on the other hand I also heard that Arteta was a bit criticized by people for rarely giving Saka a break. Honestly, this is a big problem, and it's true that Arteta must quickly find a solution to this situation, or find a replacement that will not cause a significant void in Saka's absence in the next match against Manchester City. Playing at home in my opinion is a pretty heavy responsibility, even though they will play against the strongest team in the Premier League but still the situation at home seems to require them to achieve good results, agree a draw is not bad enough if victory is not possible.
There is still hope for Arsenal to win the match since Manchester City also have injured players in the squad, and Arsenal can manage to play with Nelson and Trossard with either Jesus or Nketiah at the top, and they can get a result since their midfield is complete.