be careful with those x99 motherboards, I have a two gigabyte ones with 6800cpus and 16gb ram for max lanes and still i could not get over 4 cards to run on those boards, tried AMD and Nvidia
Fortunately I'll only be doing 4 cards. That's all that will fit.
Congrats on jumping over to Watercooling, its a bit of an expense initially, but once you get setup the benefits are awesome. I run 4 x 1080ti's on my rig on water and see around 41c temps on 4 cards tuned to 68% tdp, which was my peak hashrate per watt mark on the MSI cards i run, a little advice for ya, make sure you run a double waterpump setup... running 4 cards put a lot back pressure on my initial single D5 i was running and within a month it bit the dust on me... So replaced it under warranty, that one lasted about 2 months before it gave up.. I think the combination of excess resistance in the line along with 24/7 heat soaking the pump... it just cant handle it.. So i upgraded to 2 x D5's on a front case res.. that worked really well and my pumps ran much cooler because the PWM was making them work half as much/hard...
When i first built my mining rig on water i ran a single 60mm 360mm rad ontop of the case in a 6 fan push/pull.. it worked well but my temps stayed in the low 70's while mining, so due to lack of room i added a 1080mm Nova externally mounted rad outside of the computer case. I had it mounted on the wall of the room, but the fans rarely ever turned on due to temps dropped dramatically with the large rad added to the system. I got the bright idea when re-arranging the office around, to test hanging the 1080mm rad outside the window, the window i hung it out of was on the covered balcony, so when i tested it out there the water temp only went from 38c to 41c, but the immediate benefit was the office went from an OK manageable warm room to now chilly from most of the heat being dumped outside now...... So that is where i left it and remounted it outside on a mount. I cut a section of board with 2 holes drilled in it to run the water line through the window and seal the window up.
The above rig was my personal gaming/mining rig i ran up tell Hurricane Irma decided to take my home away from me, now im rebuilding and waiting for parts for a new personal PC. I built a AMD 1950x threadripper setup in a Thermaltake Core X9 case. I have it running on air right now, my CPU block has not showed up yet along with a few odd and ends, but i wont be running an external rad right away. Im staying at my parents house while i deal with insurance on my damage home, so i am limited on what i can and cant do really. For now i am just gonna run 3 x 480mm rads on the X9 case, 1 x sideways on the bottom layer and 2 x mounted in the top.