What actually matters is the overall profit/loss after considering all the bets that he/she placed until that point basically.
When I bump into bets of this size I wonder if what we see on a sport betting site is only part of a bigger betting strategy : I feel like they had already made bets of then size in other sportsbook on the same event taking advantage of different odds/vip Systems/cashback/promotions and stuff like that.
I tend to assume they overall will have a gain whatever will be the outcome of the event they are betting on because me, as a average Joe, can't really believe someone is really bearing the risk of losing those amounts of money.