I've been experimenting with d2, 4, 8, 10, 16, 20 and 32.
All work fine, the variance is abit wild with 32 on my CM1, it all works out over 24 hours of course, it's no bother. It's just funny to see it say I'm doing 2.1Gh/s sometimes. I believe it be more stable on for higher performance system like ASIC, that is all.
I've been mining quiet happily on diff4 recently. Might keep it there or go back to 8. 8 matches the number of chips, seemed like a nice thing to do.
*waits for someone to point out that makes no mathematical sense*