EDIT: No problems at all for my gtx760, no other cards ATM (Gigabyte 750TI is in shipment )
I have a similar problem with my EVGA 750TI SC as well, but it only happens with quark as far as I've noticed - all of a sudden, low hash/clock, and no accepted shares.
I don't reboot though. If you're on windows, just go into device manager, disable, then re-enable that card. This reloads the drivers, and re-initializes the card. Should work for you as well.
Annoying as heck, though.
Mine does this even with stock clocks, and slightly underclocked. No problems with anything else, and can usually run +65/+300
the "disabling"/"enabling" never worked for me...
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