The question is: "Speaking of btc, is nicehash a solid choice for higher return or standard multipool to take advantage of low diff? Running single gpu setup."
I believe he is using the DMD multipool because later he mentioned the Reactor payout.
if u want to mine DMD direct via groestl algo u need to use one of the other 3 pools (as visible on page 1 of this thread)
if DMD direct mining diff is to high for u try use https://multipool.bit.diamonds/
here u can use any supported hardware (asics too) and algo from nicehash and get earnings converted into DMD
DMD Multipool = Nicehash + BTC to DMD conversion (based on bot who buy at actual marketprice with 0% fees on top of nicehash fees)
if its better to mine groestl on a DMD pool or utilize DMD Multipool with nicehash deepens on ur GPU and what it can mine
AMD cards and NVIDA cards have different performances at mining deepends on the algo and miner version overclocking and stability at each algo
example i have 9x 750ti last week i did mine with 7 of them lyra2REv2 algo at DMD Multipool (via Nicehash) this week i mine x11 algo at DMD Multipool (via Nicehash)
2 of my 750ti mine groestl on cryptopools (at high overclock some cards not stable on x11 but still stable at groestl.....)
and my 2 AMD290 mining ETH (not possible over nicehash so i mine via other pool and do conversion to DMD manual)
DMD Reactor affect only DMD Cloudmining shareholder have no relation to DMD Multipool