A GPU can not operate at 100F over ambient.
In the winter, my inlet air is around 0F (or lower). My GPUs are regulated by fans to around 160F (71C). I guess mine are magical because that's a 160 degree difference and I have a few cards that are 3 years old and still doing GPGPU computation 24/7. I'll just assume that you are trying to say something different here or you are setting some specific value for "ambient" in your head...
So using car as an analogy is as dubious as using a pressurized water reactor as an analogy.
You are completely overcomplicating the argument. The original statement/arguement was that a GPU cannot be cooled with 90-100F air. I said that the statement/arguement was wrong and silly because a GPU most certainly can if you provide it with a constant supply of fresh air. You're arguing my side and apparently not realizing it.
GPU also don't work well at 345C either.
I never said or implied that they do.
If a car needed to operate at no more than 40F over ambient then cooling system would need to be radically changed.
Agreed. At only 40F over ambient, the fuel would never combust.
The cooling system could just be stripped out entirely.
Jokes aside, I'll assume you're saying "coolant temperature at only 40F over ambient" because you were apparently quoting coolant temperature before when you used the 200F figure. If you wanted a vehicle's coolant to run at only 40F above ambient on the freeway, just remove the thermostat.
No radical redesign necessary. Don't say that I didn't warn you that it'll only burn 5 percent of its fuel though.
GPU need to operate at no more than 140F (worst case scenario that is only 40F over ambient) thus car is a dubious analogy.
Err... if that's the case, then everyone who fires up Crysis 2, Furmark, OCCT, or Furmark without manually controlling their fan speed will trash their GPUs. Most of the recent ATI cards will happily run at 70-75C and will even stay stable to 80C. The clock throttle on most BIOSes are set to around 90C (194F). "No more than 140F" is pretty low. Not only is it low, but it's lower than the manufacturer sets the auto-fan profile to. They are certainly designed to run hotter. Longevity is a different argument altogether.
Are you sure that you're not confusing the term "over ambient"? This applies to water coolant temperature, but doesn't apply to air cooling (or air cooling a radiator) in the way that you are stating... Engineers don't design an air cooled device (like a video card) to run at a certain temperature over ambient. They design what temperature/temperature range the device should run at and then specify the minimum/maximum ambient temperatures that will allow it to stay within the set thermal threshold.