SecondMarket will not lose any money, no matter what the price does. When an investor gives them money for N shares, they buy N/10 bitcoins at the current market price. When the investor liquidates those N shares, they sell the N/10 bitcoins at current market price and give him that money.
If the price went down in the meantime, the investor takes the loss; if it went up, he takes the profit. In any case, SecondMarket skims off the entry, maintenance, and exit fees.
SecondMarket could make even more money if they had a private source that would sell them bitcoins below market price. That difference in price would be their extra profit.