My experience so far with Zpool has been excellent, though I admit I'm only on day 3 of testing.
The first 24 hours I mined Lyra2v2, auto-converting to VTC, and got exactly the amount of VTC my hashrate and average difficulty predicted; yes, I understand that as an auto-convert pool there will be much more variation in payout, but it's nice to see reality match theory anyway.
The next 24 hours I mined Lyra2v2, auto-converting to XVG, and received 51 vs. 53 expected - close enough for me given the above.
Now I am running NemosMiner to test Zpool in multi-algo, auto-convert to BTC mode and will be comparing it to a similar rig running NiceHash for at least 3 days. Even if Zpool doesn't win this competition I will still use it in single algo mode because it has performed far better than similar tests done at HashRefinery, MiningPoolHub, and Zergpool.
A quick update after the first 24 hours of running - NiceHash is currently ahead with 0.33331 mBTC earned vs. 0.29274 mBTC immature + earned at Zpool.
The two rigs I have set up for doing these kinds of tests consist of a single GTX 1080 that I have tuned to deliver the same Sols/s (+/0 0.5) in Equihash. The algos I have selected in NemosMiner for Zpool are:
poly,hsr,keccak,xevan,skunk,tribus,phi,skein,equihash,groestl,sib,bitcore,x17,blakecoin,Nist5,MyriadGroestl,Lyra2RE2,neoscrypt,blake2s,lyra2z
Other settings in the NemosMiner bat file are to check profitability every 60 seconds (-interval 60) and switch algos at 5% difference in profitability (-ActiveMinerGainPct 5).
For NiceHash I have all of the single algos selected except for a few that I know have been ASIC'ed: keccak, nist5, neoscrypt, Lyra2rev2, DaggerHashimoto, Cryptonight, Equihash, Pascal, Blake2s. Oops, looks like I left Pascal enabled, even though it has been ASIC'ed... Oh well, can't change it now without invalidating the test.
One other update - I got credited for 1.5 more XVG in my earlier test so that brought the total up to 52.5 actual vs. 53 predicted; again, not the most scientific of tests, since one is mining multiple coins with a single algo, then converting everything mined to one of those coins, but you really can't complain if you get exactly the amount of coin your hashrate and average difficulty predict.*
* - I am well aware that this is not a terribly accurate means of evaluating the performance of a pool or miner, but there simply isn't any other way to do it when switching coins, much less switching algos.