Phoenix,
Just an update on this issue: v5.3b seems to be moving in the right direction - all of my GPUs mine, now, but they each see about 18MH less hashrate on v5.3b versus what I still get on v5.0e. Again, with this version, downgrading to v5.0e resolves the issue without rebooting. If it's helpful, the starting hashrate for v5.3b during autotuning is only about half of what it is in v5.0e. I hope this helps.
I wanted to report an issue I ran into on v5.2e for mixed-gen ETH mining on one XFX RX 5700 8GB + one XFX RX 480 8GB + one MSI RX 480 8GB on Ubuntu 18.04.4 LTS (via minerstatOS) with amdgpu-pro v19.30 drivers. When I upgraded to v5.2e, I saw my RX 5700 take approximately an hour to build its DAG file, and then yield 0 hashrate, and the two RX 480s only produced about a third of their normal hashrate. I previously saw the same behavior with all PhoenixMiner v5.1x versions, as well.
Rolling back to v5.0e immediately resolves the issue without a reboot. I have used a few versions of the PhoenixMiner for about ten months on this mixed-gen rig without issue, so this has been something introduced after v5.0e. In case it's any help, I am including a few log excerpts, though I never saw any suspicious messages or error logs to report.
v5.2e log (note the miner uptime versus the DAG generation progress)2020.11.23:16:24:05.279: eths Eth: New job #f7c9706f from us1.ethermine.org:4444; diff: 4000MH
2020.11.23:16:24:05.536: GPU1 GPU1: DAG 92%
2020.11.23:16:24:05.866: main
2020.11.23:16:24:05.866: main *** 0:43 *** 11/23 16:24 **************************************
2020.11.23:16:24:05.866: main Eth: Mining ETH on us1.ethermine.org:4444 for 0:43
2020.11.23:16:24:05.866: main Eth speed: 22.623 MH/s, shares: 17/0/0, time: 0:43
2020.11.23:16:24:05.866: main GPUs: 1: 0.000 MH/s (0) 2: 11.801 MH/s (11) 3: 10.822 MH/s (6)
2020.11.23:16:24:05.866: main Eth: Accepted shares 17 (0 stales), rejected shares 0 (0 stales)
2020.11.23:16:24:05.866: main Eth: Incorrect shares 0 (0.00%), est. stales percentage 0.00%
2020.11.23:16:24:05.866: main Eth: Maximum difficulty of found share: 56.2 GH (!)
2020.11.23:16:24:05.866: main Eth: Average speed (5 min): 22.595 MH/s
2020.11.23:16:24:05.866: main Eth: Effective speed: 25.98 MH/s; at pool: 25.98 MH/s
2020.11.23:16:24:05.866: main
...
2020.11.23:16:27:02.493: eths Eth: New job #c61bb84f from us1.ethermine.org:4444; diff: 4000MH
2020.11.23:16:27:02.888: GPU1 GPU1: DAG 98%
2020.11.23:16:27:04.976: main GPU1: 45C 91% 53W, GPU2: 60C 100% 76W, GPU3: 50C 100% 70W
GPUs power: 199.2 W
2020.11.23:16:27:06.380: main
2020.11.23:16:27:06.380: main *** 0:46 *** 11/23 16:27 **************************************
2020.11.23:16:27:06.381: main Eth: Mining ETH on us1.ethermine.org:4444 for 0:46
2020.11.23:16:27:06.381: main Eth speed: 22.623 MH/s, shares: 18/0/0, time: 0:46
2020.11.23:16:27:06.381: main GPUs: 1: 0.000 MH/s (0) 2: 11.802 MH/s (11) 3: 10.821 MH/s (7)
2020.11.23:16:27:06.381: main Eth: Accepted shares 18 (0 stales), rejected shares 0 (0 stales)
2020.11.23:16:27:06.381: main Eth: Incorrect shares 0 (0.00%), est. stales percentage 0.00%
2020.11.23:16:27:06.381: main Eth: Maximum difficulty of found share: 56.2 GH (!)
2020.11.23:16:27:06.381: main Eth: Average speed (5 min): 22.618 MH/s
2020.11.23:16:27:06.381: main Eth: Effective speed: 25.73 MH/s; at pool: 25.73 MH/s
2020.11.23:16:27:06.381: main
...
2020.11.23:16:27:48.656: eths Eth: Received: {"id":6,"jsonrpc":"2.0","result":true}
2020.11.23:16:27:51.512: main
2020.11.23:16:27:51.512: main *** 0:47 *** 11/23 16:27 **************************************
2020.11.23:16:27:51.513: main Eth: Mining ETH on us1.ethermine.org:4444 for 0:47
2020.11.23:16:27:51.513: main Eth speed: 22.624 MH/s, shares: 19/0/0, time: 0:47
2020.11.23:16:27:51.513: main GPUs: 1: 0.000 MH/s (0) 2: 11.801 MH/s (12) 3: 10.823 MH/s (7)
2020.11.23:16:27:51.513: main Eth: Accepted shares 19 (0 stales), rejected shares 0 (0 stales)
2020.11.23:16:27:51.513: main Eth: Incorrect shares 0 (0.00%), est. stales percentage 0.00%
2020.11.23:16:27:51.513: main Eth: Maximum difficulty of found share: 56.2 GH (!)
2020.11.23:16:27:51.513: main Eth: Average speed (5 min): 22.608 MH/s
2020.11.23:16:27:51.513: main Eth: Effective speed: 26.73 MH/s; at pool: 26.73 MH/s
2020.11.23:16:27:51.513: main
2020.11.23:16:27:52.592: eths Eth: New job #aaa008e3 from us1.ethermine.org:4444; diff: 4000MH
2020.11.23:16:27:53.583: GPU1 GPU1: DAG 100%
2020.11.23:16:27:53.672: GPU1 GPU1: DAG generated in 2841.7 s (1.4 MB/s)
2020.11.23:16:27:53.673: GPU1 GPU1: Using Ethash OCL kernels (gfx1010; -clkernel 1)
2020.11.23:16:27:53.673: GPU1 GPU1: no -gt value specified, switching to auto-tune
2020.11.23:16:27:53.673: GPU1 GPU1: starting auto-tune process
v5.0e log (note the functional GPU1 and the much better hashrates for SPU2 and GPU3)Eth: New job #169100e2 from us1.ethermine.org:4444; diff: 4000MH
Eth speed: 117.353 MH/s, shares: 5/0/0, time: 0:04
GPUs: 1: 57.140 MH/s (2) 2: 30.881 MH/s (2) 3: 29.332 MH/s (1)
GPU1: 57C 89% 130W, GPU2: 71C 100% 87W, GPU3: 61C 100% 86W
GPUs power: 303.0 W