This is a tragic news. two midfielders and one defender all of them are quality players. Their absence will affect the team and that is very bad if they can't win their next game after drawing to Brighton. Don't forget that Decaknd Rice a defensive midfielder had a red card in the last match and won't be playing also in the upcoming one. This is a lot of loss for Arsenal at this early stage in the league.
Arsenal against Tottenham is a very strong game. They have to win that game. However, there will be a reshuffle in the players. Jurrnie Timber will substitute for Odegard's position. Thomas Partey will hold the defensive midfield alongside Jorginho. This will work well for the team and if they can keep the play on till the game is over.
Havertz and Trossard might likely rotate to midfielder positions, but this will make them have no player to back up on striker positions. Arsenal need to use all of their players, unfortunately they can't sign more players since the transfer window was closed.
The match will held in Tottenham stadium, this gives more disadvantage to Arsenal.
Considering Tottenham isn't in shape, I guess the match will end in draw.
Arsenal will face a very crucial and also emotional match this end week against Tottenham, so far the London derby is not just to get 3 points but more than all because of the eternal rivalry that has occurred between Arsenal and Tottenham Hotspur so far, Arsenal who will away to Tottenham Stadium currently in a bad condition after Declan Rice, Merino, Calafiori and also Odegaard must be absent in the later match, without a full squad of course Arsenal has a very small chance of winning at Tottenham home, Tottenham does not want to be embarrassed by their rivals altbough so far Tottenham has not found their best performance in the league but I am quite sure if they will play very well and full of ambition to be able to beat Arsenal in the match.
Arteta, who has lost 3 midfielders and 1 defender, of course has to find a solution to be able to keep their squad solid in the match, because so far they only have two experienced midfielders, namely Jorginho and also Partey, losing Calafiori in my opinion is not a big problem for Arsenal considering they have many defenders in their squad, but the midfield must actually be the main focus for Arsenal, because so far their midfield has been the center of Arsenal game, so when they don't have a balanced midfield it will be difficult for Arsenal to win in that the match and we can see the proof when Arsenal lost Declan Rice against Brighton in the previous match