Liverpool know-how to win "big" team, but they always have a problem with the small club who are fighting for survival. I will not be surprised if Sou vs. Liv finishes as a draw.
Perhaps, I however don't expect anything less than a win from Liverpool against Southampton, although It definitely could be a tough game, Southampton have won three of their last four EPL games, and will also be looking to add to their tally because they are still not safe from relegation.
You are quite right and since Liverpool will be playing away from home it makes the tie even trickier and they can't afford any slip here else it's Goodbye EPL title . I wouldn't bet on this game as it could swing either way but will surely be worth my weekend, I reckon.