I think the only option left with South Africa is to recall Hashim Amla and AB de Villiers to the test squad. These two players retired from the international cricket many years back and the South Africans haven't been able to replace them yet. Also, remember that de Villiers retired at the age of 33 and back then I was thinking that he had at least 4-5 years left.
In my opinion, the most significant question that can be asked is whether South Africa can avoid follow on or not. And I don't think that they will be able to score another 288 runs before they lose the remaining 8 wickets. A lot will depend on whether they will be able to avoid it or not. If they follows on, then there is no chance that they could save this match. It is going to be 3-0 for India.