After seeing the big match won by Napoli when they beat Juventus in Serie A, I am very optimistic about Napoli's ability to win at Frankfurt headquarters. Even though the atmosphere of the Champions League is very different from the Local League, Napoli has always performed well in the competition it is still following. Frankfurt benefited from starting the match at their headquarters, but the guests they faced were not just any opponents. Frankfurt needs to prepare mentally to keep from losing points at its base.
Thought winning in Serie A and winning in Europe, in Champions League are so different, Napoli did shown they can play well in Champions League too by beating Liverpool months ago.
With their very good form in this season and after World Cup 2022, Frankfurt likely will become another victim of Napoli. Frankfurt did not have more experience than Napoli in Champions League and they don't have advantage from past experience there. Napoli even had more seasons in Champions League in the last 10 years than Frankfurt too.
Serie A will put so much support for Napoli because their league need to have as many successful clubs in Champions League to maintain their national ranking for their league compares to other leagues in Europe.
I personally also hope that Napoli can beat Frankfurt in the first leg and in the second leg of the Champions League, because in my opinion Napoli have better players than Frankfurt, even though Frankfurt have two very good defenders namely Evan Ndicka and Lucas Silva Melo, but they will definitely it was difficult to withstand the onslaught of two Napoli strikers James Osimhem and Jesper Grange, because they have become Napoli's goal machine and they managed to score 12 goals and 7 goals, but predictions can change and miss, because anything can happen in a football match.
Napoli can beat Frankfurt at their home stadium in Naples because they are so strong at home. Winning Frankfurt in aggregated result will depends on Napoli performance in Germany at the home stadium of Frankfurt. In the past season, Frankfurt made a big shock by beating Barcelona so Napoli must be very careful. They look like a stronger team than Frankfurt but it is only assessment, not final result.