If Leverkusen can successfully wrap up the Europa League title then this season will be one to remember for them as they went undefeated to win the league title as well as the Europa League tournament title.
I'm sure the most difficult match will be European league final match. If Leverkusen can win the match, Leverkusen probably win all the remaining matches. There are 3 remaining matches: 1 Bundesliga match, 1 DFB Pokal final match, and 1 UEL final match. For Bundesliga and DFB Pokal match, Leverkusen are very likely to win the matches because they play against weak teams. In theory, Leverkusen only need to win UEL final match to have unbeaten status in all competitions.
The biggest obstacle for Leverkusen was Liverpool but Liverpool have already exited the tournament so now they have no big opponents to beat. This team is unbeaten in every match they have played so far this season so we have no doubts about their performance.
Atalanta can beat Liverpool, it means Atalanta is stronger than Liverpool. The biggest opponent is Atalanta, they prove it by reaching the final round. Even if Atalanta has no many popular players, it doesn't mean Leverkusen will beat them easily. Atalanta showed a great improvement in this season, they can be in UCL zone in Serie A, they can reach the final of Coppa Italia, and they can reach the final of Europa league. Leverkusen mustn't underestimate Atalanta, this team can surprise Leverkusen if they are not ready to fight in the final match.