GHOST does not address centralization, in fact it may make centralization worse. That said, having essentially instant transactions is at least a really important and relevant differentiator that might be worth a try, if we have the talent and resources on this team to implement it.
If not, then a new coin with instant transactions and privacy (and a good launch...) could be a real winner.
See the ethereum implementation with 1 min blocks. The technology is used there to prevent mining centralization and essentially "capture" orphans to secure the network. Instant tx as described in the paper is more or less handwaving.