Palmeiras has a significant difference with the second place (Fluminense).
If Palmeiras manages the games, and the other teams, for example (Fluminense, Flamengo, Corinthians and others) draw or even lose some games, they will hardly reach Palmeiras, they will possibly not be focused on winning the championship, because Palmeiras have a good advantage, but yes, they will focus to get a spot in the Libertadores.
There are still 14 games left for the end of the championship, so statistically it's possible that many teams will still manage to overcome Palmeiras.
However, technically speaking, I think this is very difficult to do.
Palmeiras have a very solid team that is doing very well not only in the Brazilian championship but also in others they play.
The only team that I believe can surpass Palmeiras is Flamengo, let's wait and see.