As Villarreal is a strong opponent, unfortunately without Ramos they're in a tough situation.
it will be hard for Real, but do not think that Villareal is a favorite neither
both teams have some injured players, Villareal actually had a good schedule so far, with five home matches and good score at home, but without "high scale" opponents, lost at Barca 4:0, and what is their best result so far is a win in Madrid suburb against Getafe, so their position at the table should be looked from that position as well
think that Real will have a good time there, win is questionable, but would not call a lost match as well