He is surely the huge favourite on this upcoming fight. In terms of going up in the weight division, I believe, Inoue's camp is also careful in increasing his weight. It is understandable to have that kind of strategy as he has reputation to keep.
Yes, it's understandable that they will be careful on his body, although he is not that young anymore and I think his body has matured and he could go only at the featherweight to Jr Lightweight and that's it for him, no more 130 lbs as he might bulk and it could affect his speed.
So let's see his body of work against Nery, although Puma is very confident in this interviews that he will beat Inoue, but let's see. I'm not saying 100% that Inoue will win and there's no chance for Nery to win. But look at how Inoue's version in the last couple of fights, hard to see how Nery can overcome Inoue.