Why 2 vs 4 card rig setup? Why do you believe this is the best setup, just asking because I'm curious and want to build a 1080 TI rig
4 card rigs are a lot harder to keep the GPUs cool, unless you use risers.
I personally prefer 3 card rigs, but current motherboards are either WAY too expen$ive to get proper 3 cards spacing for good cooling on 3 FULL LENGTH boards, or I can use the low-cost stuff and make a point of putting a "short" card in the 3'd slot (like the Gigabyte "ITX" 1070 model) to allow the middle card to have ONE fan completely clear to keep it cool enough.
3 card rigs are a LOT easier to set up then riser rigs, in my experience tend to be noticeably more reliable than riser rigs (riser rigs ARE easier to keep the GPUs cool on though), and the cost difference is very small to nothing after you factor in the cost of the risers, the extra amount of connections needed on your PS (or the extra CABLES to add to it) to power the risers, and the problem that power supply cost per watt starts climbing noticeably faster past about the 650 watt level vs the "additional costs" of 2 MB, 2 CPU, twice as much RAM, 2 HD/SSD/USB keys.
You also get the nice part that if you DO have a rig go down, you only lost HALF of your hashrate from 6 cards instead of all of it.
If I could get reliable access to that Katana-model 1070 or if someone that DOES normally sell to the US builds a similar model at a SMALL premium to 2-slot card designs, I might start going 4-card rigs regularly, as THOSE things you can keep cool fairly easily on boards like the Biostar Racer board that Phil liked that have 4 slots properly spaced to mount double-slot cards ON the motherboard.
NVidia and AMD make "compute" single-slot-wide versions of many of their higher-end GPUs but those things are CRAZY expensive definitely not a good choice for a mining machine (unless you can get a good used one for a LOT off new pricing).
The really scary part - as of this morning, the only RX 4xx boards I could find for sale anywhere (I do NOT look at eBay, too many bad experiences there) were all priced HIGHER than the low-end of the GTX 1070 - and the RX 5xx cards I could find weren't much better.
We might see a big short-term move of folks to NVidia because the "lower cost" part of the ROI question on the RX 470/480/570/580 isn't THERE any more vs the 1070.