And it shouldn't be overlooked that Lepzig is a very solid and consistent team. They've been finishing in the top 4 (Champions League places) for the last six years in a row. This should be accounted for.
If Bayer is to lose points this season, it would be to teams like this one. Personally I wouldn't be betting on this game.
Home advantage should work in favour of Bayer though, as Leipzig tended to perform better at home than in away games.
Of course head-to-head games don't guarantee anything. But they give us some ideas about betting at least. You don't need to bet on Leverkusen to win too like I said. Over 2.5 goals and 3.5 goals are both reasonable to be given a chance. You know the productivity of these teams. I don't expect to watch a boring game.
Dortmund and Bayern Munich are also highly likely to win this week. Dortmund should be able to beat Werder Bremen away. It shouldn't be a big deal. Bayern Munich are going to face Freiburg home. Freiburg had a surprising start by destroying Stuttgart. However I believe in Kompany's team not to leave any points home.